Expressions of LRP, GST-pi and MRP1 in acute leukemia patients and its clinical significance.
- Author:
Bin-Tao HUANG
1
;
Zhen XIAO
;
Yu-Tao SHI
;
Sen HA
;
Wei-Hong ZHAO
;
Da GAO
;
Xiao-Hong YAN
;
Hong YANG
Author Information
1. Department of Hematology, Affiliated Hospital, Inner Mongolia Medical College, Huhhot 010059, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette, Sub-Family B, Member 1;
biosynthesis;
genetics;
Adolescent;
Adult;
Aged;
Drug Resistance, Multiple;
genetics;
Drug Resistance, Neoplasm;
genetics;
Female;
Glutathione S-Transferase pi;
biosynthesis;
genetics;
Humans;
Leukemia, Myeloid, Acute;
drug therapy;
metabolism;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
drug therapy;
metabolism;
Vault Ribonucleoprotein Particles;
biosynthesis;
genetics
- From:
Journal of Experimental Hematology
2007;15(2):262-266
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the relationship of expressions of gluthatione-S-transferase-pi (GST-pi), multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) with multidrug resistance of acute leukemia (AL), the correlation between 3 kinds protein expressions and the correlation of their protein expression with clinical features of AL patients. The S-P immunohistochemical staining method was used to determine the expressions of GST-pi, MRP1 and LRP proteins in 80 AL patients and 30 normal subjects. The results showed that there was the correlation between GST-pi, MRP1, LRP protein expression and chemotherapy resistance, meanwhile CR rates of patients with positive expression of those proteins were lower than that of patients with negative expression (P<0.05), so those protein expressions may be accounted for poor prognosis. There was the positive relationship between expression of GST-pi and MRP1 in refractory group (r=0.851, P<0.01). It is concluded that co-examination of GST-pi and MRP1 has greater significance than examination of one kind of protein in evaluating poor prognosis of leukemia patients. LRP protein expression increase obviously when WBC counts >or= 10 x 10(9)/L (63.6%, P<0.05), therefore LRP protein has great judging value for evaluating drug resistance and prognosis of acute leukemia patients whose peripheral blood WBC counts were high.
