Inhibitory effect of ilexpernoside C from Ilex pernyi on aggregated LDL-induced foam cells formation.
- Author:
Qi-Xing LUN
1
;
Bing-Lin LIU
1
;
Jun LI
1
;
Yun-Fang ZHAO
1
;
Jiao ZHENG
1
;
Peng-Fei TU
1
Author Information
- Publication Type:Journal Article
- Keywords: Ilex pernyi; aggLDL; foam cell; ilexpernoside C
- From: China Journal of Chinese Materia Medica 2016;41(3):498-503
- CountryChina
- Language:Chinese
- Abstract: The aggregation of macrophage-derived foam cells on vascular wall is considered to be a main cause of atherosclerosis. In the present study, we evaluated the inhibitory effect of the compound ilexpernoside C (IC1) extracted from Ilex pernyi (Aquifoliaceae) on foam cell formation in THP-1 macrophages cells which were induced by low density lipoproteins aggregates (LDL aggregates). Results showed that IC1 could significantly inhibit the formation of foam cells. The analysis on related receptors of foam cells indicated that IC1 could significantly decrease the expression of low density lipoprotein-related receptor 1(LRP1). Therefore, these findings indicated that IC1 inhibited the formation of foam cells by inhibiting endocytosis of macrophages, thus it may act as a potential anti-atherosclerotic agent.
