Chemical constituents from Mylabris phalerata and their cytotoxic activity in vitro.
- Author:
Yao-Bo ZENG
1
;
Xiao-Ling LIU
1
;
Chuang-Jun LI
2
;
Xing ZHOU
1
;
Xiao-Mei ZHANG
1
;
Yong YANG
1
;
Hong-Fei DU
1
;
Chun-Bin TAN
1
;
Yu-Yu ZHANG
1
;
Yi ZHANG
1
;
Da-Jian YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Mylabris; chemical constituents; cytotoxic effect
- From: China Journal of Chinese Materia Medica 2016;41(5):859-863
- CountryChina
- Language:Chinese
- Abstract: Ten compounds were isolated from Mylabris phalerata by using preparative HPLC and column chromatography over MCI gel. On the basis of physical-chemical properties, NMR and MS data analysis, the compounds were identified as 5'-[(1 R,2 R,3 S,6R)-1-hydroxymethyl-2-methyl-3,6-epoxycyclohexane-1,2-dicarboximide]- ethyl-2'-methyl-2'-butenoate (1),cantharidin (2), cyclo-(L-Pro-L-Ala) (3), cyclo-(R-Pro-R-Leu) (4), cyclo-(S-Pro-R-Leu) (5), cyclo-(D-Pro-L-Tyr) (6), indole-3-aldehyde (7), 3-indoleacetic acid (8), valerolactam (9), and 4-hydroxyphthalid (10).Compound 1 was a new compound, and compounds 2-10 were obtained from this genus for the first time. Compounds 1-9 were subjected to cytotoxic activity on HCT-116, HepG2, BGC-823, NCI-H1650, A2780 cell lines, and only compound 2 showed inhibitory effect on all cancer cell lines.
