Peritoneal Dialysis Associated Peritonitis and Empirical Antibiotics Therapy in Korean Children with Chronic Renal Failure.
- Author:
Sang Goo LEE
1
;
Joongbum CHO
;
Young Bae SOHN
;
Sung Won PARK
;
Su Jin KIM
;
Dong Kyu JIN
;
Kyung Hoon PAIK
Author Information
1. Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea. kyunghoon.paik@samsung.com
- Publication Type:Original Article
- Keywords:
Peritonitis;
Methicillin-resistant;
Staphylococcus aureus
- MeSH:
Anti-Bacterial Agents;
Ceftazidime;
Cephalothin;
Child;
Coagulase;
Dialysis;
Humans;
Kidney Failure, Chronic;
Methicillin Resistance;
Peritoneal Dialysis;
Peritonitis;
Staphylococcus;
Staphylococcus aureus;
Streptococcus;
Vancomycin
- From:Journal of the Korean Society of Pediatric Nephrology
2008;12(2):213-220
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aims to verify the effectiveness of initial empirical antibiotic choice recommended by the International Society for Peritoneal Dialysis(ISPD) guide among Korean children. METHODS: We have collected data on peritonitis from January 2001 to December 2007 in Samsung Medical Center. RESULTS: Of the 42 patients, 48 episodes of peritonitis had occurred in 21 patients. The rate of peritonitis was one episode over 35.3 patient-months. Mean dialysis duration before peritonitis was 18.06+/-15.81 months. Gram-positive organisms accounted for 58.3% of all episodes. Of the gram-positive organisms, the most common pathogen was Staphylococcus aureus(29.2 %), the next common pathogens were Coagulase negative staphylococcus(14.6%) and Streptococcus species(6.3%). 35.7% of gram-positive pathogens were resistant to 1st cephalosporin. However, in patients younger than 4 years old, 50% of gram-positive pathogens were resistant to 1st generation cephalosporin. 10 episodes of peritonitis were methicillin-resistant and were treated by vancomycin. Of the gram-negative organisms, E. coli was the most common (8.3%). 64.8% of all pathogens were sensitive to cephalothin or ceftazidime. CONCLUSION: The empirical therapy with 1st generation cephalosporin and ceftazidime can be also effective to peritoneal dialysis associated peritonitis in Korean children. However, in patients younger than 4 years old, glycopeptide should be considered as the first empirical therapy in Korean children.
