Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease.
10.4070/kcj.2015.45.5.364
- Author:
Seon Ah JIN
1
;
Hee Jung SEO
;
Sun Kyeong KIM
;
Yu Ran LEE
;
Sunga CHOI
;
Kye Taek AHN
;
Jun Hyung KIM
;
Jae Hyeong PARK
;
Jae Hwan LEE
;
Si Wan CHOI
;
In Whan SEONG
;
Byeong Hwa JEON
;
Jin Ok JEONG
Author Information
1. Divison of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. jojeong@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
APEX1 protein, human;
Ref-1 protein, human;
Biological markers;
Coronary artery disease
- MeSH:
Acute Coronary Syndrome;
Biomarkers;
C-Reactive Protein;
Coronary Artery Disease*;
Coronary Vessels*;
DNA;
DNA Repair;
Enzyme-Linked Immunosorbent Assay;
Humans;
Inflammation;
Myocardial Infarction;
Stroke;
Troponin I
- From:Korean Circulation Journal
2015;45(5):364-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, inflammation, angiogenesis, and survival pathways. We investigated serum APE1/Ref-1 in patients with coronary artery disease (CAD). SUBJECTS AND METHODS: Serum APE1/Ref-1 was measured with a sandwich enzyme-linked immunosorbent assay from 360 patients who received coronary angiograms. They were divided into two groups; a control (n=57) and a CAD group (n=303), the latter included angina (n=128) and myocardial infarction (MI, n=175). RESULTS: The levels of APE1/Ref-1 were higher in the CAD than the control (0.63+/-0.07 vs. 0.12+/-0.07 ng/100 microL, respectively; p<0.01). They were also higher in MI than angina (0.81+/-0.10 vs. 0.38+/-0.11 ng/100 microL, respectively; p<0.01) and different according to the thrombolysis in myocardial infarction (TIMI) flow (0.88+/-0.09 for TIMI flow 0, 1, 2 vs. 0.45+/-0.13 ng/100 microL for TIMI flow 3, p<0.01) in acute coronary syndrome. In correlation analysis, the levels of APE1/Ref-1 were positively correlated with Troponin I (r=0.222; p<0.0001) and N-terminal pro-B type natriuretic peptide (NT-proBNP, r=0.217; p<0.0001) but not high sensitivity to C-reactive protein. Also, they revealed a negative correlation with ejection fraction (EF, r=-0.221; p=0.002). However, there were no significant differences among the three groups, were divided by their levels of APE1/Ref-1, for major adverse cardiovascular events (death, recurrent MI, stroke, revascularization) (8.2 vs. 14.0 vs. 12.5%, p=ns). CONCLUSION: The levels of serum APE1/Ref-1 are elevated in CAD, and are higher in MI than in angina. They are correlated with Troponin I, NT-proBNP, and EF.
