Histopathologic Predictors of Lymph Node Metastasis and Prognosis in Tonsillar Squamous Cell Carcinoma.
- Author:
Dong Jin LEE
1
;
Mi Jung KWON
;
Eun Sook NAM
;
Ji Hyun KWON
;
Jin Hwan KIM
;
Young Soo RHO
;
Hyung Sik SHIN
;
Seong Jin CHO
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Palatine tonsil;
Carcinoma, squamous cell;
Prognosis;
Lymph nodes;
Neoplasm metastasis
- MeSH:
Carcinoma in Situ;
Carcinoma, Squamous Cell;
Cell Differentiation;
Disease-Free Survival;
Humans;
Lymph Nodes;
Muscles;
Neck Dissection;
Necrosis;
Neoplasm Metastasis;
Palate, Soft;
Palatine Tonsil;
Prognosis;
Risk Factors;
Tobacco;
Tongue
- From:Korean Journal of Pathology
2013;47(3):203-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Risk factors for lymph node metastasis in tonsillar squamous cell carcinoma (TSCC) need to be established to determine the degree of surgery required to achieve high curative rates. However, little is known currently about the histopathological features predicting prognosis, specifically in TSCC. METHODS: This study included 53 patients who underwent surgical resection with neck dissection. Clinicopathological factors investigated included age, gender, alcohol use, tobacco consumption, tumor stage, adjacent structure involvement, cell differentiation, squamous dysplasia, in situ carcinoma associated with primary invasive cancer, carcinoma in situ skip lesions, necrosis, invasive front, depth of invasion, and lymphatic, muscle, or perineural invasion. RESULTS: Contralateral cervical metastasis was associated with higher T stages and soft palate invasion. Lymphatic and muscle invasion were associated with ipsilateral cervical metastasis. Advanced T stage, invasion to the base of tongue, and skip lesions were associated with decreased disease-free survival. Advanced T stage and skip lesions were associated with worse overall survival. CONCLUSIONS: Advanced T stage and soft palate invasion may predict a high risk of contralateral nodal metastasis. T stage and skip lesion are worse prognostic factors in TSCC and should be commented in pathology reports.
