Pregnancy Outcomes of Different Methods for Multifetal Pregnancy Reduction: A Comparative Study.
10.3346/jkms.2008.23.1.111
- Author:
Jung Ryeol LEE
1
;
Seung Yup KU
;
Byung Chul JEE
;
Chang Suk SUH
;
Ki Chul KIM
;
Seok Hyun KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. seokhyun@snu.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Pregnancy Reduction, Multifetal;
Pregnancy, Multiple;
Reproductive Technology, Assisted;
Pregnancy Outcome
- MeSH:
Adult;
Female;
Humans;
Potassium Chloride/therapeutic use;
Pregnancy;
*Pregnancy Outcome;
Pregnancy Reduction, Multifetal/*methods;
Retrospective Studies
- From:Journal of Korean Medical Science
2008;23(1):111-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to evaluate the outcomes of various methods of multifetal pregnancy reduction (MFPR) and to determine which method produces better outcomes. One hundred and forty-eight patients with multiple pregnancies resulting from assisted reproduction programs and underwent MFPR were included. According to the use of potassium chloride (KCl), patients were divided into 'KCl', and 'non- KCl' groups, and based on gestational age at the time of procedures, patients were divided into 'Early' (before 8 weeks of gestation) and 'Late' (at 8 weeks or later) groups. Firstly, to clarify the effect of each component of MFPR procedure, data were analyzed between 'KCl' and 'non-KCl' groups, and between 'Early' and 'Late' groups with adjustments. Secondly, comparison between 'Early, non-KCl' and 'Late, KCl' groups was performed to evaluate the combinative effect of both components. Non-KCl groups showed a significantly higher take-home-baby rate, and lower risk of extreme prematurity and preterm premature rupture of membranes (PPROM) than KCl groups. Early groups showed a lower immediate loss rate than Late groups. As compared with 'Late, KCl' group, 'Early, non-KCl' group was superior in terms of immediate loss, pregnancy loss, take-home-baby, and PPROM rates. Our data suggest that the 'Early, non-KCl' method may be a better option for MFPR.
