Compounds from a jellyfish-derived fungus Aspergillus fumigates.
10.20307/nps.2016.22.2.82
- Author:
Guan Yu TAO
1
;
Juan LIU
;
Jee H JUNG
;
Wei GUO
;
Xiao Qiong WEN
;
Yonghong LIU
Author Information
1. Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 510301 Guangzhou, China. yonghongliu@scsio.ac.cn
- Publication Type:Original Article
- Keywords:
Nemopilema nomurai;
Jellyfish-derived fungus;
Aspergillus fumigates;
Isolation;
Structural elucidation
- MeSH:
Aspergillus*;
Cell Line, Tumor;
Fungi*;
Humans
- From:Natural Product Sciences
2016;22(2):82-86
- CountryRepublic of Korea
- Language:English
-
Abstract:
Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), (22E, 24R)-24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol (3), 5α,8α-epidioxyergosta-6,22-dien-3β-o1 (4), cyclo-(L-Pro-L-Tyr) (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.
