Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production.
10.20307/nps.2016.22.2.129
- Author:
Tae Wook PARK
1
;
Chul LEE
;
Jin Woo LEE
;
Hari JANG
;
Qinghao JIN
;
Mi Kyeong LEE
;
Bang Yeon HWANG
Author Information
1. College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea. byhwang@chungbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Buddleja officinalis;
Buddlejaceae;
NO production inhibitor
- MeSH:
Buddleja*;
Lignans;
Methanol;
Monoterpenes;
Nitric Oxide*;
RAW 264.7 Cells;
Saponins;
Statistics as Topic
- From:Natural Product Sciences
2016;22(2):129-133
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.
