Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies.
- Author:
Hyun Kyu PARK
1
;
Jae Woo CHO
;
Byoung Seok LEE
;
Heejin PARK
;
Ji Seok HAN
;
Mi Jin YANG
;
Wan Jung IM
;
Do Yong PARK
;
Woo Jin KIM
;
Su Cheol HAN
;
Yong Bum KIM
Author Information
- Publication Type:Original Article
- Keywords: Cynomolgus monkey; clinical chemistry; hematology; blood coagulation; urinalysis
- MeSH: Alkaline Phosphatase; Anesthetics; Animals; Aspartate Aminotransferases; Bilirubin; Blood Coagulation; Blood Urea Nitrogen; Chemistry, Clinical; Creatinine; Erythrocytes; Fasting; Female; Hematocrit; Hematology; Humans; L-Lactate Dehydrogenase; Lactic Acid; Macaca fascicularis*; Male; Pathology, Clinical*; Phosphotransferases; Primates; Reference Values*; Rodentia; Sex Characteristics; Urinalysis
- From:Laboratory Animal Research 2016;32(2):79-86
- CountryRepublic of Korea
- Language:English
- Abstract: Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.
