Epidemiologic and Clinical features of Enteroviral Infections in Children, a Single Center Study in Korea: 2009.
- Author:
Dong Won BAEK
1
;
Jung Min KIM
;
Ki Hwan KIM
;
Jong Gyun AHN
;
Dong Soo KIM
Author Information
1. Department of Pediatrics, Yonsei University, College of Medecine, Severance Children's Hospital, Seoul, Korea. dskim6634@yuhs.ac
- Publication Type:Original Article
- Keywords:
Enterovirus;
Enterovirus 71;
Children
- MeSH:
C-Reactive Protein;
Child;
Echovirus 9;
Encephalitis;
Enterovirus;
Female;
Fever;
Herpangina;
Humans;
Male;
Meningitis, Aseptic;
Myocarditis;
Sex Ratio
- From:Korean Journal of Pediatric Infectious Diseases
2010;17(2):122-129
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Enteroviral infection is a common viral illness in children. We undertook this study in attempt to comprehend the epidemiologic and clinical features of enteroviral infections, particularly EV71 in children. METHODS: We enrolled 63 children with enteroviral infection at Severance Children's Hospital in Seoul between May and August 2009. Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed from stool or cerebrospinal fluid samples, which were then tested for enteroviral infection. Viral isolation and serotype identification also were performed by RT-PCR. RESULTS: A total of 63 patients with clinical diagnosis of enteroviral infections were enrolled; of those, 38 (60%) were positive for enterovirus. The mean age of the patients was 2 years and 7 months and the sex ratio of male to female was 0.9:1. Their clincal manifestations included aseptic meningitis (21 cases, 55%), HFMD (16 cases, 42%), herpangina (5 cases, 13%), neonatal fever (2 cases, 5%), encephalitis (1 case, 3%), and myocarditis (1 case, 3%). Serotypes of isolated enteroviruses were EV71 (8 cases, 21%), coxsackievirus B1 (8 cases, 21%), coxsackievirus A16 (2 cases, 6%), coxsakievirus A2 (1 case, 3%), coxsakievirus A5 (1 case, 3%), and echovirus 9 (1 case, 3%). Clinical symptoms of EV71 infection included HFMD (5 cases, 63%), aseptic meningitis (3 cases, 38%), encephalitis (1 case, 13%), and myocarditis (1 case, 13%). A positive rate of C-reactive protein in EV71 was higher than those in other enterviral infections. However, there was no statistically significant difference in other laboratory findings. CONCLUSION: We reported on identified enteroviruses, including EV71, during a period of 3 months in the summer of 2009. In this study, EV71 infection frequently occurred in male and clinical manifestation caused by EV71 was a more severe disease than that due to other enterviral infections. There is a need for continuous surveillance of enteroviral infection and its clinical manifestations for diagnosis and treatment of enteroviral infection.
