The Change of Tumor Interstitial Fluid Pressure by Radiation Therapy in Patients with Metastatic Lymph Node in Head and Neck Area.
- Author:
Moon June CHO
1
;
Jae Sung KIM
;
Intae LEE
;
Jun Sang KIM
;
Ji Young JANG
;
Ki Hwan KIM
Author Information
1. Department of Therapeutic Radiology, College of Medicine, Chungnam National University.
- Publication Type:Original Article
- Keywords:
Tumor intersitial fluid pressure;
Radiotherapy;
Head and neck cancer
- MeSH:
Biopsy;
Extracellular Fluid*;
Head and Neck Neoplasms;
Head*;
Humans;
Lymph Nodes*;
Neck*;
Needles;
Palpation;
Radiotherapy
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
2000;18(2):127-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with metastatic lymph node in head and neck area can predict radiotherapy outcome. MATERIALS AND METHODS: In 26 biopsy proven metastatic lymph node patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (>1 cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy. Tumor size was measured clinically and radiologically. RESULTS: The mean preradiotherapy TIFP was 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased ( p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less respone ( p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP ( p=0.229). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone. CONCLUSION: The mean TIFP was elevated with 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups.
