Impact of Post-Stroke Cognitive Impairment with No Dementia on Health-Related Quality of Life.
- Author:
Jung Hyun PARK
1
;
Beom Joon KIM
;
Hee Joon BAE
;
Jisung LEE
;
Juneyoung LEE
;
Moon Ku HAN
;
Kyung Yoon O
;
Seong Ho PARK
;
Yeonwook KANG
;
Kyung Ho YU
;
Byung Chul LEE
Author Information
1. Department of Neurology, Dongguk University Gyeongju Hospital, Gyeongju, Korea.
- Publication Type:Original Article
- Keywords:
Quality of life;
Stroke;
Dementia
- MeSH:
Cognition;
Dementia;
Geriatrics;
Humans;
Magnetic Resonance Imaging;
Quality of Life;
Stroke
- From:Journal of Stroke
2013;15(1):49-56
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D, compared the findings to those of healthy people with normal cognition, and evaluated the influence of each cognitive domain on this score. METHODS: In total, 1,528 subjects were identified who had undergone neuropsychological assessment using the 60-min protocol of the Korean version of Vascular Cognitive Impairment Harmonization Standards, EQ-5D, and magnetic resonance imaging at the stroke prevention clinic. Fifty PSCIND patients were matched to 50 post-stroke dementia (PSD) patients and 50 normal age- (+/-3 years) and sex-matched controls. The effects of PSCIND, PSD, and control groups upon the EQ-5Dindex score were tested by generalized estimating equation modeling. RESULTS: Estimated means+/-standard errors of EQ-5Dindex scores were as follows: 0.94+/-0.06 (control group), 0.86+/-0.08 (PSCIND group), and 0.61+/-0.32 (PSD group); and the difference among the three groups was statistically significant (P<0.0001). Pairwise comparisons showed that EQ-5Dindex scores in the PSCIND group differed from those in the PSD and control groups (both P<0.01). No cognitive domain was specifically associated with EQ-5Dindex scores after adjusting for functional status. CONCLUSIONS: This study shows that PSCIND may interfere with the quality of life in stroke victims.
