Clinical Characteristics of Patients with Autoimmune Pancreatitis with or without Mikulicz's Disease and Mikulicz's Disease Alone.
- Author:
Sawako KURUMA
1
;
Terumi KAMISAWA
;
Taku TABATA
;
Seiichi HARA
;
Takashi FUJIWARA
;
Go KUWATA
;
Hideto EGARASHIRA
;
Koichi KOIZUMI
;
Keigo SETOGUCHI
;
Junko FUJIWARA
;
Takeo ARAKAWA
;
Kumiko MOMMA
;
Toshio MITSUHASHI
;
Tsuneo SASAKI
Author Information
1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. kamisawa@cick.jp
- Publication Type:Original Article
- Keywords:
Autoimmune pancreatitis;
Mikulicz' disease;
Immunoglobulin G;
IgG4-related disease;
Steroid therapy
- MeSH:
Diabetes Mellitus;
Humans;
Immunoglobulin G;
Mikulicz' Disease;
Pancreatitis;
Recurrence;
Salivary Glands
- From:Gut and Liver
2013;7(1):96-99
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The objective of this study was to compare the clinical characteristics of patients with autoimmune pancreatitis (AIP) with or without Mikulicz's disease (MD) and with MD alone. METHODS: We investigated the clinical findings in 15 AIP patients with MD (group A+M), 49 AIP only patients (group A), and 14 MD only patients (group M). RESULTS: The male-female ratio was significantly higher in group A+M (73%, p<0.05) and group A (78%, p<0.01) than group M (21%). Serum immunoglobulin G (IgG) levels were significantly higher in group A+M than in group A (p<0.01) and group M (p<0.05). Serum IgG4 levels were significantly higher in group A+M than in group A (p<0.01). Other organ involvement was observed in 73% (11/15) of patients in group A+M. The number of patients with diabetes mellitus was significantly higher in group A+M (66%, p<0.01) and group A (51%, p<0.05) than in group M (7%). All of the patients responded well to steroid therapy, but the relapse rate in group A+M (33%) was significantly higher than that in group A (3%, p<0.01). Salivary gland function was impaired in all groups compared with the control group, but the degree of dysfunction was less in group A compared with group A+M and group M. CONCLUSIONS: The relapse rate of AIP in MD patients was significantly higher than that of AIP in patients without MD.
