The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application.
- Author:
Dong Ha KIM
1
;
Yun Young LIM
;
Hyeong Mi KIM
;
So Young KIM
;
Beom Joon KIM
;
Sung Gil PARK
;
Taehoon LEE
;
Soo Muk CHO
Author Information
1. Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-755, Korea. beomjoon@unitel.co.kr
- Publication Type:Original Article
- Keywords:
PS-SPCL;
Safety;
Skin irritation test;
SFKLRY-NH2;
W3 peptide
- MeSH:
Korea;
Oligopeptides;
Peptide Library;
Skin;
United States Food and Drug Administration
- From:Toxicological Research
2012;28(1):51-56
- CountryRepublic of Korea
- Language:English
-
Abstract:
A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH2 on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH2 in HaCaT cells and B16F10 cells. SFKLRY-NH2 induced no skin irritation at low concentration (10 microM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH2 in clinical use.
