Mixed Exocrine and Endocrine Carcinoma in the Stomach: A Case Report.
10.5230/jgc.2011.11.2.122
- Author:
Han Hong LEE
1
;
Chan Kwon JUNG
;
Eun Sun JUNG
;
Kyo Young SONG
;
Hae Myung JEON
;
Cho Hyun PARK
Author Information
1. Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine, Seoul, Korea. chpark@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Stomach neoplasms;
Neuroendocrine tumor;
Adenocarcinoma
- MeSH:
Adenocarcinoma;
Carcinoma, Neuroendocrine;
Cytoplasm;
Endoscopy, Digestive System;
Gastrectomy;
Humans;
Lymph Node Excision;
Middle Aged;
Neuroendocrine Tumors;
Stomach;
Stomach Neoplasms;
Synaptophysin
- From:Journal of Gastric Cancer
2011;11(2):122-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a rare case of the coexistence of a gastric small cell neuroendocrine carcinoma with a gastric adenocarcinoma. A 62-year-old man presented with epigastric soreness for 1 month. Esophagogastroduodenoscopy revealed a Borrmann type I tumor at the lesser curvature of the lower body of the stomach. The patient underwent a distal gastrectomy with D2 lymph node dissection and the resected specimen exhibited a 3.5x3.5 cm sized, fungating lesion. Two separated, not intermingling, lesions with non-adenocarcinoma components encircled by well differentiated adenocarcinoma components were identified microscopically. The non-adenocarcinoma component showed neuroendocrine features, such as a solid and trabecular pattern, and the tumor cells showed a high nuclear grade with minimal cytoplasm, indistinct nucleoli, and positive response for synaptophysin, CD56. The final pathological diagnosis was a gastric mixed exocrine-endocrine carcinoma (MEEC) composed of an adenocarcinoma and small cell neuroendocrine carcinoma of the collision type.
