Relationship between the low-density lipoprotein cholesterol level and clinical outcome after percutaneous coronary intervention in patients with acute myocardial infarction.
- Author:
Kyung Hoon CHO
1
;
Myung Ho JEONG
;
Keun Ho PARK
;
Min Goo LEE
;
Jum Suk KO
;
Shin Eun LEE
;
Won Yu KANG
;
Soo Hyun KIM
;
Doo Sun SIM
;
Nam Sik YOON
;
Hyun Ju YOUN
;
Young Joon HONG
;
Hyung Wook PARK
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Cardiovascular Research Center of Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Myocardial infarction;
Low-density lipoprotein cholesterol;
Percutaneous coronary intervention
- MeSH:
C-Reactive Protein;
Cholesterol;
Creatinine;
Diabetes Mellitus;
Humans;
Hypertension;
Lipoproteins;
Male;
Myocardial Infarction;
Myocardial Ischemia;
Percutaneous Coronary Intervention;
Risk Factors;
Smoke;
Smoking;
Stroke Volume
- From:Korean Journal of Medicine
2009;76(6):692-700
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: This study examined the relationship between the low-density lipoprotein cholesterol (LDL-C) level and clinical outcome after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). METHODS: Between January 2006 and December 2007, 867 patients (age, 62.6+/-12.5 years; males, 71%) undergoing a 1-year follow- up after PCI for AMI were divided into five groups according to the LDL-C level: <70, 70-100, 100-130, 130-160, and > or =160 mg/dL. RESULTS: Smoking (63%), hypertension (46%), and diabetes mellitus (28%) were common risk factors. The history of ischemic heart disease decreased as the LDL-C level increased (p=0.036). Patients with lower LDL-C levels had lower creatinine clearance and higher high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. The rate of in-hospital complications after PCI declined with increases in the LDL-C level, except in patients with LDL-C >160 mg/dL (linear p=0.010). There was no correlation between the LDL-C level and the 30-day or 1-year clinical outcome after PCI. After multivariate adjustment, independent predictors of the 1-year mortality after PCI were left ventricular ejection fraction, hsCRP, age, and creatinine clearance. CONCLUSIONS: Higher LDL-C levels were related to fewer in-hospital complications, but there was no correlation between the LDL-C level and long-term clinical outcome after PCI in Korean patients with AMI.
