Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes.
- Author:
Elizabeth C MOLINA
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
buffaloes;
cattle;
cytokines;
Fasciola gigantica
- MeSH:
Animals;
Buffaloes/blood/immunology/*parasitology;
Cattle;
Cattle Diseases/*immunology/*parasitology;
Cytokines/*blood/immunology;
Enzyme-Linked Immunosorbent Assay/veterinary;
Fasciola/*immunology;
Fascioliasis/immunology/parasitology/*veterinary;
Interferon Type II/blood;
Interleukin-6/blood;
Interleukin-8/blood;
Random Allocation
- From:Journal of Veterinary Science
2005;6(2):135-139
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study investigated the presence of cytokines interferon (IFN)-gamma, interleukins (IL) -6 and -8 in serum of cattle and buffaloes infected with Fasciola gigantica from one to 16 weeks post-infection to determine their T cell response during infection. The concentration of these cytokines was determined by sandwich enzyme-linked immunosorbent assay (ELISA). No IFN-gamma was detected in these animals while IL-6 was elevated from one to 16 weeks postinfection. Levels of IL-8 were also elevated in infected buffaloes from one to 16 weeks post-infection. A predominantly T helper (Th) 2 response which started early in the infection was apparently present in cattle and buffaloes in this study which was characterised by IL-6. IL-8 production could be another mechanism of immune response in buffaloes during infection with F. gigantica.
