Immunoglobulin E-mediated hypersensitivity reaction after intraperitoneal administration of vancomycin.
10.1016/j.krcp.2014.09.005
- Author:
Mun Ju HWANG
1
;
Jun Young DO
;
Eun Woo CHOI
;
Joon Hyuk SEO
;
Yoon Jung NAM
;
Kyung Woo YOON
;
Jong Won PARK
;
Kyu Hyang CHO
;
Seok Hui KANG
;
Hyun Jung JIN
Author Information
1. Division of Nephrology, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Korea. jydo@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Hypersensitivity;
Intraperitoneal administration;
Peritoneal dialysis;
Vancomycin
- MeSH:
Female;
Flushing;
Humans;
Hypersensitivity*;
Immunoglobulins*;
Peritoneal Dialysis;
Peritoneal Dialysis, Continuous Ambulatory;
Peritonitis;
Pruritus;
Sensation;
Skin Tests;
Urticaria;
Vancomycin*
- From:Kidney Research and Clinical Practice
2015;34(1):57-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
Intraperitoneal (IP) vancomycin is widely used to treat Gram-positive peritonitis associated with peritoneal dialysis. There have been two cases of red man syndrome (RMS), a vancomycin-specific nonimmunologic reaction, associated with IP vancomycin. However, immune-mediated hypersensitivity reaction to IP vancomycin has not yet been reported. A 49 year old woman on continuous ambulatory peritoneal dialysis developed her first peritonitis episode. The patient was treated with IP vancomycin once/wk for 4 weeks. She experienced mild itching and flushing throughout her body for 1 day after the second treatment. Whenever vancomycin was administered, generalized urticaria and a prickling sensation developed, and the intensity increased gradually; however, these symptoms improved after vancomycin was discontinued. An allergic skin test was performed 6 weeks after the previous urticarial episode, and an intradermal skin test revealed a positive response to vancomycin. To our knowledge, this is the first case report of immunoglobulin E-mediated hypersensitivity reaction to IP vancomycin administration.
