Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis.
10.3349/ymj.2016.57.3.776
- Author:
Mantao CHEN
1
;
Zuoxu FAN
;
Xiujue ZHENG
;
Fei CAO
;
Liang WANG
Author Information
1. Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. zd05lcyxcmt@sina.com
- Publication Type:Meta-Analysis ; Original Article ; Research Support, Non-U.S. Gov't ; Review
- Keywords:
Noise;
smoking;
allergy;
acoustic neuroma;
meta-analysis
- MeSH:
Adult;
Asthma/complications;
Environmental Exposure/*adverse effects;
Female;
Humans;
Hypersensitivity;
*Leisure Activities;
Neuroma, Acoustic/epidemiology/*etiology;
Noise/*adverse effects;
Occupational Exposure/adverse effects;
Risk Factors;
Smoking/adverse effects
- From:Yonsei Medical Journal
2016;57(3):776-783
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Many epidemiological studies have investigated environmental risk factors for the development of acoustic neuroma. However, these results are controversial. We conducted a meta-analysis of case-control studies to identify any potential relationship between history of noise exposure, smoking, allergic diseases, and risk of acoustic neuroma. MATERIALS AND METHODS: We searched PubMed to identify relevant articles. Two researchers evaluated the eligibility and extracted the data independently. RESULTS: Eleven case-control studies were included in our meta-analysis. Acoustic neuroma was found to be associated with leisure noise exposure [odds ratio (OR)=1.33, 95% confidence interval (CI): 1.05-1.68], but not with occupational noise exposure and ever noise exposure (OR=1.20, 95% CI: 0.84-1.72 and OR=1.15, 95% CI: 0.80-1.65). The OR of acoustic neuroma for ever (versus never) smoking was 0.53 (95% CI: 0.30-0.94), while the subgroup analysis indicated ORs of 0.95 (95% CI: 0.81-1.10) and 0.49 (95% CI: 0.41-0.59) for ex-smoker and current smoker respectively. The ORs for asthma, eczema, and seasonal rhinitis were 0.98 (95% CI: 0.80-1.18), 0.91 (95% CI: 0.76-1.09), and 1.52 (95% CI: 0.90-2.54), respectively. CONCLUSION: Our meta-analysis is suggestive of an elevated risk of acoustic neuroma among individuals who were ever exposed to leisure noise, but not to occupational noise. Our study also indicated a lower acoustic neuroma risk among ever and current cigarette smokers than never smokers, while there was no significant relationship for ex-smokers. No significant associations were found between acoustic neuroma and history of any allergic diseases, such as asthma, eczema, and seasonal rhinitis.
