A Case of Disseminated Infection Due to Scedosporium apiospermum in a Liver-transplantation Recipient.
- Author:
Jae Woo CHUNG
1
;
Sook Ja PARK
;
Heungsup SUNG
;
Mi Na KIM
;
Bum Soo KIM
;
Sung Gyu LEE
Author Information
1. Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. mnkim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Scedosporium apiospermum;
Liver transplantation;
Disseminated infection;
Voriconazole
- MeSH:
Amphotericin B;
Aneurysm, Infected;
Anti-Bacterial Agents;
Brain;
Brain Abscess;
Cyclosporine;
Female;
Fibrosis;
Fungi;
Humans;
Korea;
Liver;
Liver Transplantation;
Living Donors;
Methylprednisolone;
Middle Aged;
Mortality;
Pneumonia;
Pseudallescheria;
Scedosporium*;
Thorax;
Transplantation
- From:The Korean Journal of Laboratory Medicine
2005;25(6):421-424
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Scedosporium apiospermum, an anamorph of Pseudallescheria boydii, is a ubiquitous saprophytic mold. Now a day, S. apiospermum is an emerging pathogen related to a significant morbidity and high mortality in transplant recipients. For the first time in Korea, we report a case of disseminated infection caused by S. apiospermum after liver transplantation. A 47-year-old woman underwent living donor liver transplantataion for billiary cirrhosis. She was treated with cyclosporine A, methylprednisolone, and prophylactic antibiotics including amphotericin B. She was found to have developed pneumonia and brain abscess at postoperative day 9 and 17 by chest X-ray and brain CT, respectively. Cultures of endotracheal aspirates and aspirates of brain abscess yielded S. apiospermum. Despite of antifungal therapy with amphotericin B, voriconazole, and caspofungin and removal of mycotic aneurysm of the brain, the patient died on postoperative day 33.
