Sorafenib-induced Syringoma-like Eccrine Duct Proliferation in a Patient with Hepatocellular Carcinoma.
- Author:
Joon Bum LEE
1
;
Kyu Suk LEE
;
Byung Ho OH
;
Sung Ae KIM
Author Information
1. Department of Dermatology, School of Medicine, Keimyung University, Daegu, Korea. skksasf@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Sorafenib;
Syringoma;
Hepatocellular carcinoma
- MeSH:
Adult;
Aged;
Biopsy;
Carcinoma, Hepatocellular*;
Dermis;
Eyelids;
Female;
Humans;
Skin;
Syringoma
- From:Korean Journal of Dermatology
2017;55(4):246-248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Syringomas are common benign neoplasms that are derived from the intradermal eccrine duct and frequently manifest in adult females as 1~3-mm flesh-colored papules on the face, especially on the lower eyelid. There are two hypotheses about their pathogenesis: ductal obstruction by keratin plugs and reactive eccrine proliferation following an inflammatory condition. The patient was a 66-year-old man with multiple erythematous papules and nodules on both periorbital areas after 7-day sorafenib (Nexavar®) treatment. A skin biopsy of the Rt. periorbital lesion revealed multiple cysts and tadpole-shaped tubular structures in the dermal layer. Inflammatory cell infiltration was seen throughout the dermis. Based on the clinical features and histological findings, we diagnosed the patient with syringoma-like eccrine duct proliferation. The indications for and use of Sorafenib have increased recently. Although sorafenib-associated cutaneous side effects have increased, no cases of syringoma-like eccrine duct proliferation have been reported to date. Here we report a case of sorafenib-induced syringoma-like eccrine duct proliferation in a patient with hepatocellular carcinoma.
