Expression of Actin-bundling Protein Fascin and its Relationship with Altered E-cadherin and beta-catenin Expressions in Ovarian Serous Neoplasms.
- Author:
Eun Yoon CHO
1
;
YoonLa CHOI
;
Seoung Wan CHAE
;
Eo Jin KIM
;
Kyehyun KIM
;
Geung Hwan AHN
;
Jin Hee SOHN
Author Information
1. Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea.jhpath.sohn@samsung.com
- Publication Type:Original Article
- Keywords:
Ovary, Serous neoplasms;
Fascin;
Metastasis
- MeSH:
beta Catenin*;
Cadherins*;
Dendritic Cells;
Epithelial Cells;
Female;
Humans;
Neoplasm Metastasis;
Neurons;
Ovary;
Recurrence;
Survival Rate;
Up-Regulation
- From:Korean Journal of Pathology
2005;39(4):258-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background : Fascin, an actin-bundling protein, has been found in specialized normal cells, including the neuronal, endothelial and dendritic cells, and its expression is known to be greatly increased in various human neoplasms. Methods : Immunohistochemical stainings for fascin, betacatenin, and E-cadherin were performed in normal ovary tissue (n=13), and in benign (n=14), borderline (n=32), and malignant (n=74) ovarian serous neoplasms. We evaluated the fascin expression, and its relationship with the betacatenin and E-cadherin expressions, as well as the clinicopathologic factors. Results : Fascin expression was detected in the majority of the borderline (100%, 32/32) and malignant tumors (90.5%, 67/74), but it was not seen in the normal ovarian surface epithelial cells and the benign tumors (p<0.001). Fascin expression was significantly correlated with the occurrence of peritoneal metastases in the carcinomas (p=0.043). A significant relationship between the expressions of fascin and betacatenin (p=0.046), as well as E-cadherin (p=0.035) was noted. There was no significant correlation with the tumor grade of carcinoma, the FIGO stage, tumor recurrence, tumor-related death and the survival rate. Conclusions : In ovarian serous neoplasms, the fascin expression may be closely linked with tumor progression and metastasis, and it was associated with the up-regulation of betacatenin and E-cadherin.
