Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow.
10.3346/jkms.2012.27.6.614
- Author:
Hyun Ju YOON
1
;
Myung Ho JEONG
;
Sook Hee CHO
;
Kye Hun KIM
;
Min Goo LEE
;
Keun Ho PARK
;
Doo Sun SIM
;
Nam Sik YOON
;
Young Joon HONG
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Endothelium;
Coronary Artery;
Carotid Intima
- MeSH:
Aged;
Angina, Unstable/complications/physiopathology/ultrasonography;
Brachial Artery/physiopathology;
*Carotid Intima-Media Thickness;
Coronary Angiography;
Coronary Circulation/*physiology;
Dyslipidemias/complications;
Endothelium, Vascular/*physiopathology;
Female;
Heart Rate;
Homocysteine/metabolism;
Humans;
Leukocyte Count;
Male;
Middle Aged;
Monocytes/cytology;
ROC Curve;
Regression Analysis;
Risk Factors
- From:Journal of Korean Medical Science
2012;27(6):614-618
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 +/- 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 +/- 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow.
