Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-kappaB-signaling Pathway.
10.4062/biomolther.2014.080
- Author:
Bora KIM
1
;
Jin Eun KIM
;
Byung Kook CHOI
;
Hyun Soo KIM
Author Information
1. Skin & Bio Research, Ellead Co., Ltd., Seongnam 463-824, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Trapa japonica Flerov.;
Water chestnut;
Anti-inflammatory effect;
Cytokine;
NF-kappaB
- MeSH:
Eleocharis*;
Erythema;
Humans;
Necrosis;
NF-kappa B;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Plants;
Reactive Oxygen Species;
Regeneration;
RNA, Messenger;
Skin;
Sodium Dodecyl Sulfate
- From:Biomolecules & Therapeutics
2015;23(1):90-97
- CountryRepublic of Korea
- Language:English
-
Abstract:
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-alpha- and interleukin-6-induced nuclear factor-kappaB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.
