Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma.
- Author:
Hae Sim PARK
1
;
Soo Keol LEE
;
Young Mok LEE
;
Sun Sin KIM
;
Dong Ho NAHM
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
TDI-induced asthma;
Specific IgE;
Specific IgG;
Half-life
- MeSH:
Adult;
Asthma/*chemically induced/immunology;
Biological Markers/blood;
Human;
Immunoglobulin E/blood/*immunology;
Immunoglobulin G/blood/*immunology;
Longitudinal Studies;
Male;
Middle Aged;
Serum Albumin/*immunology;
Support, Non-U.S. Gov't;
Toluene 2,4-Diisocyanate/adverse effects/*immunology
- From:The Korean Journal of Internal Medicine
2002;17(4):249-251
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation suggested a role of specific IgG (sIgG) in the development of TDI asthma. METHODS: We observed the changes in the levels of specific IgE and IgG antibodies to TDIHSA conjugate in TDI-induced asthmatic patients during seven years avoidance. RESULTS: Six subjects with high sIgE and five with high sIgG were enrolled. All of them had taken anti-asthmatic medications with complete avoidance. Serum levels of sIgE and sIgG to TDI-HSA conjugate were detected by ELISA. The level of sIgE continued to decline up to 7 years and the mean half-life was 3.9 years. The mean half-life of sIgG was 4.5 yrs. CONCLUSION: These findings suggest that both sIgE and sIgG to TDI-HSA conjugate may persist for several years after the last exposure to TDI.
