Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells.
- Author:
Hye Young KIM
1
;
Min PARK
;
Kyong KIM
;
Yu Mi LEE
;
Mee Ra RHYU
Author Information
1. Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute, Songnam 463-746, Republic of Korea. khyey@kfri.re.kr
- Publication Type:Original Article
- Keywords:
Hesperetin;
Cholecystokinin;
Intracellular Ca2+;
TRP ankyrin 1;
Enteroendocrine cells
- MeSH:
Appetite;
Cholecystokinin*;
Citrus sinensis;
Enteroendocrine Cells;
Hesperidin;
Obesity
- From:Biomolecules & Therapeutics
2013;21(2):121-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on suppressive effects on appetite. This study examined that hesperetin and hesperidin can stimulate the release of cholecystokinin (CCK), one of appetite-regulating hormones, from the enteroendocrine STC-1 cells, and then examined the mechanisms involved in the CCK release. Hesperetin significantly and dose-dependently stimulated CCK secretion with an EC50 of 0.050 mM and increased the intracellular Ca2+ concentrations ([Ca2+]i) compared to the untreated control. The stimulatory effect by hesperetin was mediated via the entry of extracellular Ca2+ and the activation of TRP channels including TRPA1. These results suggest that hesperetin can be a candidate biomolecule for the suppression of appetite and eventually for the therapeutics of obesity.
