Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy.
- Author:
Yong Gil KIM
1
;
Jong Ryul EUN
;
Tae Nyeun KIM
;
Heon Ju LEE
;
Jae Woon KIM
;
Jay Chun CHANG
;
Sung Su YUN
;
Joon Hyuk CHOI
Author Information
1. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. dreun@ynu.ac.kr
- Publication Type:Case Report
- Keywords:
Hepatocellular carcinoma;
Portal vein tumor thrombosis;
Chemotherapy;
5-fluorouracil;
Complete remission
- MeSH:
Carcinoma, Hepatocellular;
Cisplatin;
Fluorouracil;
Follow-Up Studies;
Hepatectomy;
Humans;
Liver;
Male;
Middle Aged;
Necrosis;
Portal Vein;
Thrombosis
- From:Gut and Liver
2010;4(2):266-269
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT.
