Localized Darier's Disease Mimicking Lichen Simplex Chronicus on the Back.
- Author:
Hyerang ON
1
;
Mi Ryung ROH
Author Information
1. Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. karenroh@yuhs.ac
- Publication Type:Case Report
- Keywords:
Darier's disease;
Lichen simplex chronicus
- MeSH:
Acantholysis;
Biopsy;
Edible Grain;
Darier Disease*;
Diagnosis, Differential;
Hot Temperature;
Humans;
Male;
Middle Aged;
Neurodermatitis*;
Parakeratosis;
Skin;
Solar System;
Sweat;
Sweating;
Ultraviolet Rays
- From:Korean Journal of Dermatology
2014;52(10):732-734
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Darier's disease is an autosomal dominant acantholytic skin disorder. The disease is characterized by symmetric distribution of hyperkeratotic papules in seborrheic regions of the skin and nail changes with potential for exacerbation by ultraviolet light, heat, occlusion, or stress. It presents as generalized (hypertrophic or vesiculobullous type) or localized (linear or zosteriform type) condition. A 53-year-old male patient presented with hyperkeratotic verrucous papules on the back that had an onset in childhood. Clinically, his condition resembled lichen simplex chronicus. The lesions were exacerbated by sun exposure or sweating. A 3-mm punch biopsy specimen revealed prominent acantholysis with hyperkeratosis and parakeratosis. Numerous corps grains and corps ronds were present near the granular layer. We report a case of localized Darier's disease mimicking lichen simplex chronicus on the back. The skin lesion improved following treatment with a topical corticosteroid. Localized Darier's disease should be considered as one of the differential diagnoses of lichen simplex chronicus on the back.
