The Clinical Value of Intima-media Thickness in Patients with Stable Coronary Artery Disease and C-reactive Protein within Normal Limits.
- Author:
Jong Bum KWON
1
;
Kuhn PARK
;
Si Young CHOI
;
Chan Beom PARK
;
Yong Hwan KIM
;
Sung Ho HER
;
Mahn Won PARK
;
Jong Ho LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Korea. phenix@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Carotid arteries;
Atherosclerosis;
Coronary artery disease;
C-reactive protein
- MeSH:
Angina, Stable;
Atherosclerosis;
C-Reactive Protein;
Carotid Arteries;
Carotid Intima-Media Thickness;
Constriction, Pathologic;
Coronary Artery Disease;
Coronary Vessels;
Glycosaminoglycans;
Humans;
Logistic Models;
Phenobarbital;
Risk Factors
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2010;43(5):482-489
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to determine whether hand-measured carotid intima-media thickness (IMT) was a reliable and simple tool that could be used to evaluate the severity of stable coronary artery disease (CAD) with normal high-sensitivity C-reactive protein (CRP). MATERIAL AND METHOD: We examined left carotid IMTs in 688 patients with stable CAD and excluded 121 patients with abnormally elevated hs-CRP (> or =0.5 mg/dL). We sought to determine the association between risk factors and the severity of stable CAD and carotid IMT in 567 patients who were divided into lower and higher groups based on the median value. Patients underwent a coronary artery angiogram and had at least significant stenosis (>50% of the original luminal diameter involving one or more major coronary artery). RESULT: Of the 567 patients, 300 (52.9%) were in the lower IMT group and 267 (47.1%) were in the higher IMT group; the median value was 0.76 mm. By multivariable logistic regression analysis, the following groups were different: older age (~49 vs. 70~ years, respectively; OR=6.552), high FBS (~99 vs. 120~ mg/dL; OR=1.713) and severity of CAD (1 vessel vs. 2 vessel disease; OR=1.711, 1 vessel vs. 3 vessel disease; OR=1.714). CONCLUSION: We conclude that there are correlations between increased carotid IMT and severity of CAD in stable angina patients with normal CRP levels.
