The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma.
- Author:
Seung Woo LEE
1
;
Young Yong AHN
;
Yon Soo KIM
;
Sang Beum KANG
;
Soon Woo NAM
;
Dong Soo LEE
;
Hyun Yong JEONG
;
Jin Man KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. endoscope@hanmail.net
- Publication Type:Original Article
- Keywords:
Colon;
Signal transducers and activators of transcription 3;
B-cell lymphoma-extra large;
Matrix metalloproteinase-2
- MeSH:
Adenocarcinoma;
Adenoma;
Antibodies;
B-Lymphocytes;
Cell Transformation, Neoplastic;
Colon;
Colorectal Neoplasms;
Cytokines;
Humans;
Intercellular Signaling Peptides and Proteins;
Lymph Nodes;
Matrix Metalloproteinase 2;
Neoplasm Metastasis;
Prognosis;
Proteins;
Transcription Factors;
Transducers
- From:Gut and Liver
2012;6(1):45-51
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2). The aim of this study was to investigate the immunohistochemical expression of STAT3, B-cell lymphoma-extra large (Bcl-xL), and MMP-2 proteins according to histopathological parameters in colon adenocarcinomas, including lymph node metastasis, tumor differentiation, the TNM stage and the tumor size. METHODS: Immunohistochemical staining with monoclonal STAT3, Bcl-xL, and MMP-2 antibodies was performed on paraffin-embedded specimens from 20 colon adenomas and 39 adenocarcinomas. RESULTS: The expression of STAT3, Bcl-xL, and MMP-2 was increased in the adenocarcinomas as compared with the adenomas (p<0.001). STAT3 expression was stronger in tumors with a distant metastasis than in tumors without a distant metastasis (p=0.012). A larger tumor size was related to an increase in STAT3 expression (p=0.035). CONCLUSIONS: STAT3, Bcl-xL, and MMP-2 may play important roles in the tumorigenesis of colorectal carcinoma. STAT3 may be indicative of a poor prognosis due to its correlation with distant metastases and a larger tumor size.
