Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways.
10.4167/jbv.2016.46.4.288
- Author:
Zahid MANZOOR
1
;
Irshad ALI
;
Doobyeong CHAE
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, School of Medicine and Brain Korea 21 PLUS Program, Jeju National University, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Acrosorium polyneurum;
Mitogen-activated protein kinase;
NF-κB;
Nitric oxide;
Pro-inflammatory cytokine
- MeSH:
Hominidae;
Humans;
Interleukin-6;
Interleukins;
Macrophages;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Phosphorylation;
Tumor Necrosis Factor-alpha
- From:Journal of Bacteriology and Virology
2016;46(4):288-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the antiinflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor (TNF)-α. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of IκBα. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.
