Long Term Follow-up Results of External Beam Radiotherapy as Primary Treatment for Retinoblastoma.
10.3346/jkms.2010.25.4.546
- Author:
Sang Yul CHOI
1
;
Mi Sook KIM
;
SungYul YOO
;
ChulKoo CHO
;
YoungHoon JI
;
KumBae KIM
;
YoungSeok SEO
;
Kyung Duk PARK
;
JunAh LEE
;
Tai Won LEE
Author Information
1. Department of Ophthalmology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Retinoblastoma;
External Beam Radiotherapy;
Complication
- MeSH:
Child;
Child, Preschool;
Eye Enucleation;
Female;
Humans;
Infant;
Korea;
Male;
Radiotherapy/*methods;
Radiotherapy Dosage;
Retinal Neoplasms/*radiotherapy;
Retinoblastoma/*radiotherapy;
Retrospective Studies;
Survival Rate;
Treatment Outcome
- From:Journal of Korean Medical Science
2010;25(4):546-551
- CountryRepublic of Korea
- Language:English
-
Abstract:
The authors reviewed their experiences of external beam radiotherapy (EBR) as an initial treatment in retinoblastoma patients to determine its long-term effect on subsequent tumor control and complications. A total of 32 eyes in 25 patients that underwent EBR for retinoblastoma were reviewed retrospectively. The patients consisted of 21 boys and 4 girls of median age at treatment of 7.1 months. Radiation doses ranged from 35 to 59.4 Gy. The 10-yr ocular and patient survivals were 75.4% and 92.3%, respectively. Nine of the 32 eyes progressed; 7 of these were enucleated and 2 were salvaged by focal treatment. According to the Reese-Ellsworth classification, 4 of 5 eyes of Group II, 13 of 16 Group III eyes, 2 of 4 Group IV eyes, and 5 of 7 Group V eyes were retained, and of the 32 eyes, 13 had visual acuity better than 20/200. Eleven patients experienced a radiation-induced complication. No patient developed a second malignancy during follow-up. Despite the limited number of patients enrolled, EBR may provide a mean of preserving eyeball and vision for some advanced lesions.
