Does Polyethylene Glycol (PEG) Plus Ascorbic Acid Induce More Mucosal Injuries than Split-Dose 4-L PEG during Bowel Preparation?.
- Author:
Min Sung KIM
1
;
Jongha PARK
;
Jae Hyun PARK
;
Hyung Jun KIM
;
Hyun Jeong JANG
;
Hee Rin JOO
;
Ji Yeon KIM
;
Joon Hyuk CHOI
;
Nae Yun HEO
;
Seung Ha PARK
;
Tae Oh KIM
;
Sung Yeon YANG
Author Information
- Publication Type:Comparative Study ; Original Article ; Randomized Controlled Trial
- Keywords: Colonoscopy; Bowel preparation; Polyethylene glycols; Ascorbic acid; Mucosal injury
- MeSH: Adult; Ascorbic Acid/administration & dosage/*adverse effects; Cathartics/administration & dosage/*adverse effects; Colonoscopy/methods; Drug Therapy, Combination; Female; Humans; Intestinal Mucosa/drug effects/*injuries; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Polyethylene Glycols/administration & dosage/*adverse effects; Preoperative Care/*adverse effects/methods; Surveys and Questionnaires; Vitamins/administration & dosage/adverse effects
- From:Gut and Liver 2016;10(2):237-243
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The aims of this study were to compare the bowel-cleansing efficacy, patient affinity for the preparation solution, and mucosal injury between a split dose of poly-ethylene glycol (SD-PEG) and low-volume PEG plus ascorbic acid (LV-PEG+Asc) in outpatient scheduled colonoscopies. METHODS: Of the 319 patients, 160 were enrolled for SD-PEG, and 159 for LV-PEG+Asc. The bowel-cleansing efficacy was rated according to the Ottawa bowel preparation scale. Patient affinity for the preparation solution was assessed using a questionnaire. All mucosal injuries observed during colonoscopy were biopsied and histopathologically reviewed. RESULTS: There was no significant difference in bowel cleansing between the groups. The LV-PEG+Asc group reported better patient acceptance and preference. There were no significant differences in the incidence or characteristics of the mucosal injuries between the two groups. CONCLUSIONS: Compared with SD-PEG, LV-PEG+Asc exhibited equivalent bowel-cleansing efficacy and resulted in improved patient acceptance and preference. There was no significant difference in mucosal injury between SD-PEG and LV-PEG+Asc. Thus, the LV-PEG+Asc preparation could be used more effectively and easily for routine colonoscopies without risking significant mucosal injury.
