A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer.
10.4046/trd.2009.67.2.145
- Author:
Young Il KIM
1
;
Kyu Sik KIM
;
Eui Ryoung HAN
;
Yong Soo KWAN
;
In Jae OH
;
Sung Chul LIM
;
Young Chul KIM
Author Information
1. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea. cyberkks@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Etoposide;
Anaphylaxis;
Small cell lung carcinoma;
Skin tests
- MeSH:
Anaphylaxis;
Dyspnea;
Etoposide;
Female;
Humans;
Middle Aged;
Podophyllotoxin;
Skin Tests;
Small Cell Lung Carcinoma;
Urticaria
- From:Tuberculosis and Respiratory Diseases
2009;67(2):145-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.
