IL-5 Promoter Polymorphism Enhances IgE Responses to Staphylococcal Superantigens in Adult Asthmatics.
10.4168/aair.2013.5.2.106
- Author:
Purevsuren LOSOL
1
;
Seung Hyun KIM
;
Eui Kyung HWANG
;
Yoo Seob SHIN
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Brief Communication
- Keywords:
Asthma;
eosinophilic inflammation;
IL-5;
polymorphism;
staphylococcal enterotoxin
- MeSH:
Adult;
Asthma;
Enterotoxins;
Genotype;
Haplotypes;
Humans;
Immunoglobulin E;
Interleukin-5;
Lifting;
Methacholine Chloride;
Phenotype;
Polymorphism, Genetic;
Prevalence;
Superantigens
- From:Allergy, Asthma & Immunology Research
2013;5(2):106-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interleukin 5 (IL-5) is a key cytokine involved in the induction of T-helper type 2 (Th2) responses in the asthmatic airway. We investigated IL-5 genetic polymorphisms associated with asthma phenotypes, including IgE responses to staphylococcal enterotoxins A and B (SEA and SEB, respectively), in asthmatics. Adult asthmatics (n=310) and normal controls (n=160) were enrolled in the present study. Serum total and specific IgE to SEA and SEB were measured. Two IL-5 polymorphisms, -746A>G and +4499T>G, were genotyped using the primer-extension method. There were no significant differences in genotype or haplotype frequencies of these polymorphisms between the two groups. Asthmatics carrying the AG/GG genotype at -746A>G had a significantly higher prevalence of serum specific IgE to SEA (P=0.008), higher total IgE levels (P=0.014), and lower PC20 methacholine levels (P=0.002) compared to those with the AA genotype. These findings suggest that the IL-5 promoter polymorphism at -746A>G enhances serum total and specific IgE responses to SEA, which may augment airway hyperresponsiveness in adult asthmatics.
