The Clinical Effects of Drug-Eluting Stents for the Treatment of Coronary In-Stent Restenosis.
10.4070/kcj.2005.35.6.443
- Author:
Kye Hun KIM
1
;
Myung Ho JEONG
;
Seo Na HONG
;
Kyung Ho YUN
;
Sang Yup LIM
;
Sang Hyun LEE
;
Dong Goo KANG
;
Yeon Sang LEE
;
Ji Hyun LIM
;
Young Joon HONG
;
Hyung Wook PARK
;
Ju Han KIM
;
Weon KIM
;
Il Suk SOHN
;
Jae Young RHEW
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Science, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Stents;
Coronary diseases;
Coronary restenosis
- MeSH:
Angioplasty, Balloon;
Classification;
Coronary Disease;
Coronary Restenosis;
Drug-Eluting Stents*;
Follow-Up Studies;
Hospitalization;
Humans;
Myocardial Infarction;
Stents;
Thrombosis
- From:Korean Circulation Journal
2005;35(6):443-447
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Treating coronary in-stent restenosis (ISR) has become one of the major challenges for the interventional cardiologist. The aim of this study was to determine the feasibility and safety of treating ISR with drug eluting stents (DESs), and we also wanted to determine the effect of DESs on the prevention of recurrent restenosis. SUBJECTS AND METHODS: Eighty patients (age range: 60.9+/-6.4 year-old, males:females=63:17) with 82 ISR lesions that were treated successfully with DES (sirolimus- and paclitaxel-eluting stents) were enrolled in our study. Five patients received 2 stents for a total mean of 1.1+/-0.3 stents per lesion. The major adverse cardiac events (MACEs) during hospitalization, at 30 days and at 6 months after the stenting were analyzed along with the coronary angiographic findings. RESULTS: At the time of DES implantation, the mean number of ISRs was 1.4+/-0.9, and the patterns of ISR according to the Mehran classification were IB in 9 lesions (10.5%), IC in 3 lesions (3.7%), ID in 6 lesions (7.3%), II in 19 lesions (23.2%), III in 30 lesions (36.7%), and IV in 15 lesions (18.3%). The mean stent length was 27.1+/-5.6 mm and the mean acute gain was 2.58+/-0.67 mm. No in-hospital MACE was observed. During the 30-day clinical follow-up, one patient developed acute myocardial infarction due to a subacute stent thrombosis. Forty two patients with 43 lesions underwent a 6-month follow-up coronary angiogram. The mean late loss at 6 months was 0.30+/-0.74 mm. The binary restenosis rate was 9.3% (4/43 lesion). The restenosed lesions were treated by balloon angioplasty in three lesions and by additional DES implantation in one lesion. CONCLUSION: Our results demonstrated that DES was a safe and very effective method for the treatment of ISR.
