Decreased CD5+ B cells during the acute phase of Kawasaki disease.
- Author:
Hee Soo KIM
1
;
Geun Woong NOH
;
Dong Soo KIM
;
Ki Young LEE
;
Hee Sun LEE
;
Hong Kyu LEE
;
Soon Il LEE
Author Information
- Publication Type:Original Article
- Keywords: CD5+B cell; Kawasaki disease; IVIG
- MeSH: Acute Disease; Antigens, CD5/*analysis; B-Lymphocytes/*immunology; Child; Child Preschool; Female; Human; Infant; Male; Mucocutaneous Lymph Node Syndrome/*immunology/physiopathology; Reference Values
- From:Yonsei Medical Journal 1996;37(1):52-58
- CountryRepublic of Korea
- Language:English
- Abstract: We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p< 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p< 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.
