Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies.
- Author:
Gi Su OH
1
;
Hyung Jin KIM
;
AiHua SHEN
;
Su Bin LEE
;
Dipendra KHADKA
;
Arpana PANDIT
;
Hong Seob SO
Author Information
- Publication Type:Review
- Keywords: Cisplatin; Chemotherapy; Nephrotoxicity; NAD+
- MeSH: Cisplatin; Diuretics; DNA Damage; Drug Therapy; Humans; Kidney*; Oxidative Stress; Prevalence
- From:Electrolytes & Blood Pressure 2014;12(2):55-65
- CountryRepublic of Korea
- Language:English
- Abstract: Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxicity is still high, occurring in approximately one-third of patients who have undergone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.
