Differences of the Clinical Manifestations and Laboratory Tests between Monosensitized and Polysensitized Children: A Single Center Study.
10.7581/pard.2011.21.4.277
- Author:
Jong Ho LEE
1
;
Ji Hyun KIM
;
Sin Weon YUN
;
Young Shin HAN
;
Kangmo AHN
;
Soo Ahn CHAE
;
In Seok LIM
;
Eung Sang CHOI
;
Byung Hoon YOO
Author Information
1. Department of Pediatrics, Chung-Ang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Allergy;
Skin Prick Test;
Food Sensitivity;
Pulmonary Function Test
- MeSH:
Eosinophil Cationic Protein;
Eosinophils;
Food Hypersensitivity;
Forced Expiratory Volume;
Humans;
Hypersensitivity;
Immunoglobulin E;
Immunoglobulins;
Medical Records;
Methacholine Chloride;
Phenotype;
Respiratory Function Tests;
Retrospective Studies;
Skin
- From:Pediatric Allergy and Respiratory Disease
2011;21(4):277-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The objective of this study was to identify differences in the clinical manifestations and allergic indices between monosensitized and polysensitized children. METHODS: We reviewed retrospective data from the medical records of patients who had chronic or recurrent respiratory symptoms and visited the pediatric clinic at Chung-Ang University Hospital for an evaluation of allergic diseases from January 2003 to January 2011. The patients were categorized into nonsensitized (n=111), monosensitized (n=149), and polysensitized (n=205) groups according to skin prick tests (as classified by five allergen groups). We compared gender, age, family history, admission history, food sensitization, total immunoglobulin E (IgE), peripheral eosinophil counts, eosinophil cationic protein (ECP) levels, forced expiratory volume in 1 second (FEV1), and methacholine provocation tests among the three groups. RESULTS: The frequency of food sensitivity was highest in the polysensitized group (n=101, 49.3%), followed by the monosensitized (n=8, 5.4%) and nonsensitized groups (n=0) (P<0.001). The FEV1 was significantly lower in the polysensitized group than that in the monosensitized and nonsensitized groups (79.4+/-20.2% vs. 87.2+/-16.0% vs. 87.6+/-17.1%, respectively) (P=0.013). The total IgE and ECP levels were significantly higher in the polysensitized patients than those in the other patients (P<0.001 and <0.001, respectively). Differences in gender, age, peripheral eosinophil count, and bronchial hyper-responsiveness were not identified between the monosensitized and polysensitized groups. CONCLUSION: The polysensitized group showed more frequent food hypersensitivity, lower FEV1 values, and higher allergic indices such as total IgE and ECP, suggesting a different atopic phenotype compared with those in the monosensitized group.
