TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population.
10.3346/jkms.2015.30.10.1423
- Author:
Seung Soo YOO
1
;
Sook Kyung DO
;
Jin Eun CHOI
;
Shin Yup LEE
;
Jaehee LEE
;
Seung Ick CHA
;
Chang Ho KIM
;
Jae Yong PARK
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Lung Cancer Risk;
Polymorphism;
Telomere Length;
TERT
- MeSH:
Adenocarcinoma/epidemiology/*genetics;
Case-Control Studies;
Female;
Gene Frequency/genetics;
Genetic Association Studies;
Genetic Predisposition to Disease;
Humans;
Lung Neoplasms/epidemiology/*genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide/*genetics;
Promoter Regions, Genetic/*genetics;
Republic of Korea/epidemiology;
Telomerase/*genetics;
Telomere/physiology;
Telomere Homeostasis/*genetics
- From:Journal of Korean Medical Science
2015;30(10):1423-1428
- CountryRepublic of Korea
- Language:English
-
Abstract:
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
