Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori.
- Author:
Jae Hyun SEO
1
;
Su Jin HONG
;
Jie Hyun KIM
;
Byung Wook KIM
;
Sam Ryong JEE
;
Woo Chul CHUNG
;
Ki Nam SHIM
;
Gwang Ho BAIK
;
Sung Soo KIM
;
Sang Gyun KIM
;
Jin Il KIM
Author Information
- Publication Type:Original Article
- Keywords: Natural course; Helicobacter negative; Peptic ulcer disease
- MeSH: Endoscopy; Follow-Up Studies; Helicobacter pylori*; Helicobacter*; Humans; Korea; Male; Peptic Ulcer*; Recurrence*; Renal Insufficiency, Chronic; Retrospective Studies; Ulcer
- From:Gut and Liver 2016;10(5):719-725
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. METHODS: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. RESULTS: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, male, and comorbid chronic kidney disease. CONCLUSIONS: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, male, and comorbid chronic kidney disease.
