Anti-osteoporotic and Antioxidant Activities by Rhizomes of Kaempferia parviflora Wall. ex Baker.
10.20307/nps.2016.22.1.13
- Author:
Nguyen Phuong THAO
1
;
Bui Thi Thuy LUYEN
;
Sang Hyun LEE
;
Hae Dong JANG
;
Young Ho KIM
Author Information
1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. yhk@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Kaempferia parviflora;
Zingiberaceae;
Antioxidant;
Anti-osteoporosis;
TRAP
- MeSH:
Acid Phosphatase;
Osteoclasts;
Plants, Medicinal;
Rhizome*;
Zingiberaceae*
- From:Natural Product Sciences
2016;22(1):13-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this report, we investigated the antioxidant (peroxyl radical-scavenging and reducing capacities) and anti-osteoporotic activities of extracts and isolated constituents (1 - 16) from the rhizomes of Kaempferia parviflora Wall. ex Baker on pre-osteoclastic RAW 264.7 cells. Compound 5 exhibited significant peroxyl radical-scavenging capacity, with TE value of 8.47 ± 0.52 µM, while compound 13 showed significant reducing capacity, with CUPRAC value of 5.66 ± 0.26 µM, at 10.0 µM. In addition, flavonoid compounds 2, 4, 6, 8, 10, 12, and terpene compound 15 showed significant inhibition of tartrate-resistant acid phosphatase (TRAP) in NF-κB ligand-induced osteoclastic RAW 264.7 cells, with values ranging from 16.97 ± 1.02 to 64.67 ± 2.76%. These results indicated that K. parviflora could be excellent sources for the antioxidant and anti-osteoporotic traditional medicinal plants.
