HRCT Findings of Bleomycin-Related Lung Toxicity: A Report of 2 Case.
10.3348/jkrs.1997.36.1.83
- Author:
Jeong Geun YI
1
;
Won Ho JANG
;
Dae Young YOON
;
Sang Hoon BAE
Author Information
1. Department of Radiology, Colllege of Medicine, Hallym University.
- Publication Type:Case Report
- Keywords:
Bleomycin;
Computed tomography(CT), high-resolution;
Lung, CT;
Lung, fibrosis
- MeSH:
Bleomycin;
Humans;
Incidence;
Lung Diseases;
Lung*;
Lymphoma;
Oxygen;
Radiography, Thoracic;
Teratocarcinoma
- From:Journal of the Korean Radiological Society
1997;36(1):83-86
- CountryRepublic of Korea
- Language:English
-
Abstract:
Many drugs can result in a variety of pathologic reactions in the lung, especially the cytotoxic drugs. Amongcytotoxic drugs bleomycin is a prototype. Bleomycin-related pulmonary toxicity is usually known as dose-dependent and can be enhanced with concurrent oxygen therapy, irradiation, or other chemotherapeutic agents. The incidence of bleomycin-induced pulmonary toxicity has been reported as varying from 2 to 46%, and 1% of fatal lung disease. We describe the radiographic and HRCT findings of bleomycin-related pulmonary toxicity developed in two patients: one in ovarian teratocarcinoma, the other malignant lymphoma patient. Chest radiographs and HRCT of these patients showed ground-glass opacities, consolidation, linear and reticular opacities, and interlobular septal thickening. These abnormalities were bilateral, and symmetrical and were found predominantly in the area of mid-and lower-lung zone.
