A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome.
- Author:
Jee Ae KIM
1
;
Young Min LIM
;
Eun Hye JANG
;
Kwang Kuk KIM
Author Information
- Publication Type:Case Report
- Keywords: myasthenia gravis; Lambert-Eaton myasthenic syndrome; overlap syndrome; repetitive nerve stimulation tests
- MeSH: Deglutition; Diplopia; Edrophonium; Extremities; Female; Humans; Lambert-Eaton Myasthenic Syndrome; Middle Aged; Myasthenia Gravis; Steroids
- From:Journal of Clinical Neurology 2012;8(3):235-237
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The coexistence of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) is very rare and remains controversial. CASE REPORT: A 48-year-old woman initially presented with noticeable right ptosis and intermittent diplopia. She then developed fluctuating proximal limb weakness and difficulty in swallowing. The serum titer of anti-acetylcholine-receptor antibody was elevated and the edrophonium (Tensilon) test was positive. However, repetitive nerve stimulation revealed abnormalities typical of LEMS. The patient exhibited a good response to treatment with anticholinesterase inhibitors and steroids, and long-term evaluation disclosed that she presented with the clinical, electrophysiological, and immunological characteristics of both diseases. CONCLUSIONS: The reported clinical and electrophysiological features suggest that this patient was a very rare case of combined MG and LEMS.
