The Short Term Effects of Bimatoprost on Optic Nerve Head and Peripapillary Retinal Blood Flow.
- Author:
Sun Woong KIM
1
;
Chan Yun KIM
;
Gong Je SEONG
Author Information
1. The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. gjseong@yumc.yonsei.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Bimatoprost;
Ocular Blood flow;
Optic nerve head;
Peripapillary retina
- MeSH:
Blood Pressure;
Female;
Healthy Volunteers;
Heart Rate;
Humans;
Intraocular Pressure;
Male;
Ophthalmic Solutions;
Optic Disk*;
Optic Nerve*;
Retina;
Retinaldehyde*;
Bimatoprost
- From:Journal of the Korean Ophthalmological Society
2004;45(8):1322-1329
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To demonstrate the effects of bimatoprost on the optic nerve head (ONH) and peripapillary retinal blood flow. METHODS: Sixteen healthy volunteers were recruited. In a randomized, double-blind design, one eye received a drop of bimatoprost and the other eye a drop of placebo. ONH and peripapillary retinal blood flow parameters (flow, volume, velocity) were measured with HRF before, and at 1, 6 and 24 hours after eyedrops and blood pressure (BP), heart rate (HR), and intraocular pressure (IOP) were recorded. RESULTS: The 16 subjects comprised 13 males and 3 females with a mean age of 27.3 +/- 2.4 years. IOP decreased significantly in the bimatoprost-treated eyes at 1, 6 and 24 hours after eyedrops (p<0.05). BP and HR were unchanged after bimatoprost eyedrops. The flow was significantly higher in the temporal peripapillary retina in the bimatoprost-treated eyes 1 hour after eyedrops and the velocity was also higher 6 hours after eyedrops at the same location. At the optic disc, there was a significant increase of the volume in the bimatoprost group 1 hour after eyedrops. There was no significant decrease of HRF parameters in the bimatoprost-treated eyes. CONCLUSIONS: These results suggest that bimatoprost does not have any adverse effect on ONH or peripapillary retinal blood flow.
