A Case of Lacrimal Gland MALT Lymphoma in a Patient with Primary Sjögren's Syndrome.
10.3341/jkos.2016.57.7.1159
- Author:
Hyo Won KIM
1
;
Yoon Mi SUNG
;
Ji Sun BAIK
;
Suk Woo YANG
Author Information
1. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yswoph@hanmail.net
- Publication Type:Case Report
- Keywords:
Autoimmune disease;
Behcet's disease;
Lymphoma of lacrimal gland;
Mucosa-associated lymphoid tissue (MALT) lymphoma;
Sjögren's syndrome
- MeSH:
Autoimmune Diseases;
Biopsy;
Cyclophosphamide;
Diagnosis, Differential;
Drug Therapy;
Eyelids;
Female;
Humans;
Lacrimal Apparatus*;
Lymphoid Tissue;
Lymphoma;
Lymphoma, B-Cell, Marginal Zone*;
Middle Aged;
Neoplasm Metastasis;
Positron-Emission Tomography;
Prednisone;
Rituximab;
Vincristine
- From:Journal of the Korean Ophthalmological Society
2016;57(7):1159-1164
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of lacrimal gland mucosa-associated lymphoid tissue (MALT) lymphoma in a patient with primary Sjögren's syndrome and Behcet's disease. CASE SUMMARY: A 49-year-old female patient with primary Sjögren's syndrome and Behcet's disease presented with a one-year history of painless upper and lower eyelid swelling in her right eye. Lacrimal gland incisional biopsy was performed, and the patient was diagnosed with malignant lymphoma (extranodal marginal zone B cell lymphoma of MALT). No distant metastases were detected on whole-body computed tomography or positron emission tomography, and the patient was treated with Rituximab, Cyclophosphamide, Vincristine, Prednisone (R-CVP) regimen chemotherapy. After 8 consecutive chemotherapy cycles, her eyelids appeared normal externally, and partial regression was found radiologically. CONCLUSIONS: The possibility of MALT lymphoma should be considered as a differential diagnosis if patients with autoimmune diseases such as primary Sjögren's syndrome show eyelid swelling or palpable mass.
