The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean.
10.3346/jkms.2013.28.8.1213
- Author:
Ju Seung KIM
1
;
Sung Min AHN
;
Young Kul JUNG
;
Oh Sang KWON
;
Yun Soo KIM
;
Duck Joo CHOI
;
Ju Hyun KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, Incheon, Korea. 93cool@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Hepatitis C, Chronic;
Ribavirin;
Anemia;
ITPA;
IL28B
- MeSH:
Adult;
Alleles;
Antiviral Agents/therapeutic use;
Asian Continental Ancestry Group/*genetics;
Cohort Studies;
Drug Therapy, Combination;
Female;
Genotype;
Hemoglobins/*analysis;
Hemolysis;
Hepacivirus/genetics;
Hepatitis C, Chronic/drug therapy/*genetics;
Humans;
Interferon-alpha/therapeutic use;
Interleukins/genetics;
Male;
Middle Aged;
Polyethylene Glycols/therapeutic use;
Pyrophosphatases/*genetics;
Recombinant Proteins/therapeutic use;
Republic of Korea;
Retrospective Studies;
Ribavirin/therapeutic use;
Treatment Outcome
- From:Journal of Korean Medical Science
2013;28(8):1213-1219
- CountryRepublic of Korea
- Language:English
-
Abstract:
Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P=0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P=0.282), and by 78% and 71% (P=0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.
