Perfusion MR Imaging in Gliomas: Comparison with Histologic Tumor Grade.
- Author:
Sun Joo LEE
1
;
Jae Hyoung KIM
;
Young Mee KIM
;
Gyung Kyu LEE
;
Eun Ja LEE
;
In Sung PARK
;
Jin Myung JUNG
;
Kyeong Hun KANG
;
Taemin SHIN
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Brain neoplasms, MR; Brain, blood flow; Cerebral blood vessels, flow, dynamics; Magnetic resonance (MR), contrast enhancement
- MeSH: Adult; Astrocytoma/*pathology; Brain/pathology; Brain Neoplasms/*pathology; Cerebrovascular Circulation; Contrast Media; Female; Gadolinium DTPA/diagnostic use; Glioblastoma/*pathology; Human; *Magnetic Resonance Imaging; Male; Support, Non-U.S. Gov't
- From:Korean Journal of Radiology 2001;2(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To determine the usefulness of perfusion MR imaging in assessing the histologic grade of cerebral gliomas. MATERIALS AND METHODS: In order to determine relative cerebral blood volume (rCBV), 22 patients with pathologically proven gliomas (9 glioblastomas, 9 anaplastic gliomas and 4 low-grade gliomas) underwent dynamic contrast-enhanced T2*-weighted and conventional T1- and T2-weighted imaging. rCBV maps were obtained by fitting a gamma-variate function to the contrast material concentration versus time curve. rCBV ratios between tumor and normal white matter (maximum rCBV of tumor / rCBV of contralateral white matter) were calcu-lated and compared between glioblastomas, anaplastic gliomas and low-grade gliomas. RESULTS: Mean rCBV ratios were 4.90'+/-1.01 for glioblastomas, 3.97'+/-0.56 for anaplastic gliomas and 1.75'+/-1.51 for low-grade gliomas, and were thus sig-nificantly different; p < .05 between glioblastomas and anaplastic gliomas, p <.05 between anaplastic gliomas and low-grade gliomas, p < .01 between glioblas-tomas and low-grade gliomas. The rCBV ratio cutoff value which permitted dis-crimination between high-grade (glioblastomas and anaplastic gliomas) and low-grade gliomas was 2.60, and the sensitivity and specificity of this value were 100% and 75%, respectively. CONCLUSION: Perfusion MR imaging is a useful and reliable technique for esti-mating the histologic grade of gliomas.
