Thrombocytosis as a prognostic marker in stage III and IV serous ovarian cancer.
10.5468/ogs.2014.57.6.457
- Author:
Antonia DIGKLIA
1
;
Ioannis A VOUTSADAKIS
Author Information
1. Department of Medical Oncology, University Hospital of Lausanne, Lausanne, Switzerland. ivoutsadakis@yahoo.com
- Publication Type:Original Article
- Keywords:
Blood platelets;
Ovarian neoplasms;
Prognosis;
Serous histology;
Thrombocytosis
- MeSH:
Adenocarcinoma;
Blood Platelets;
Diagnosis;
Disease-Free Survival;
Follow-Up Studies;
Humans;
Ovarian Neoplasms*;
Platelet Count;
Prognosis;
Retrospective Studies;
Thrombocytosis*
- From:Obstetrics & Gynecology Science
2014;57(6):457-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Thrombocytosis is an adverse prognostic factor in many types of cancer. We investigated if pre-treatment increased platelet counts provide prognostic information specifically in patients with stage III and IV serous ovarian cancer which is the most common clinical presentation of ovarian cancer. METHODS: Platelet number on diagnosis of stage III and IV serous ovarian adenocarcinoma was evaluated in 91 patients for whom there were complete follow-up data on progression and survival. Survival and progression free survival of patients with normal platelet counts (150-350 x10(9)/L) was compared with that of patients with thrombocytosis (>350x10(9)/L) by chi2 and logrank tests. RESULTS: The median age of the patients was 66 years-old. From the 91 patients, 52 (57.1%) had normal platelet counts (median, 273x10(9)/L; range, 153-350) at diagnosis of their disease and 39 patients (42.9%) had thrombocytosis (median, 463x10(9)/L; range, 354-631). In the group of patients with normal platelet counts, 24 of the 52 patients had died with a median survival of 43 months (range, 3-100). In the group of patients with thrombocytosis, 24 of the 39 patients had died with a median survival of 23 months (range, 4-79). In the entire group of 91 patients there was a statistically significant difference of the overall survival and progression-free survival between the two groups (logrank test P=0.02 and P=0.007, respectively). CONCLUSION: In this retrospective analysis of stage III and IV ovarian cancer patients, thrombocytosis at the time of diagnosis had prognostic value regarding overall survival and progression-free survival.
